Issue #161

and there is a clash in the longevity industry - is this a good thing?

July 10, 2025

July 10, 2025 | Issue #161

Hey... What're your thoughts on this controversial medicine?

In this week's newsletter:🍄‍🟫 Trippy⚔️ Longevity Clash

Psychedelics Back, Again

New research is (again) sparking excitement about psychedelics like psilocybin, the active compound in magic mushrooms, as a potential key to extending lifespan. The study reveals that psilocybin may promote longevity by enhancing cellular repair and reducing inflammation in the body.Conducted on animal models, the research showed that low doses of psilocybin improved metabolic function and increased resilience to age-related stress, leading to a modest but significant increase in lifespan.Scientists believe these effects stem from psilocybin’s ability to modulate serotonin receptors, which influence mood, cognition, and systemic health. This discovery is important because it suggests psychedelics could do more than treat mental health conditions like depression, as they might address aging at a cellular level.With global populations aging rapidly, finding ways to extend healthspan is critical. Psilocybin’s potential to reduce chronic inflammation (a key driver of age-related diseases like heart disease and dementia) could pave the way for new anti-aging therapies. Other psychedelics, like LSD, are also showing promise.In a previous article, we covered how LSD may enhance neuroplasticity and reduce oxidative stress, both linked to longer life.We've also discussed how psychedelics improve mitochondrial function, which powers cells and declines with age.These findings align with the psilocybin study, suggesting a broader trend: psychedelics may act as “cellular tune-ups” for aging bodies. While human trials are still needed, the implications are profound.Could a carefully dosed psychedelic regimen become part of future longevity protocols? As research progresses, psychedelics might shift from counterculture stigma to mainstream medicine, offering not just a trip but a ticket to a longer life.See ya,

CodyFounder, Spannr

  • Scientists Begin Groundbreaking Study on How We Age (SciTechDaily)

  • The Longevity Business Is Booming—and Its Scientists Are Clashing (WSJ)

  • How fast are you ageing? Ordinary brain scans reveal the pace (Nature)

  • Could Psilocybin Be The Magical Ingredient For A Longer Life? (Study Finds) 

  • Why the 40s are the best time to start the longevity lifestyle (ToI)

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